One of the difficulties is maintaining a very long MINIMUM distance between her feet and the seat during riding as she is limited to how much she can bend her knee even when unloaded.
A regular step through can be adjusted to give that distance but, if the pedals are far off the ground that means that she has to get onto a higher seat than if the bottom bracket was lower. She cannot well manage that as she has a fused ankle. the other foot isn't so crash hot either.
So essentially she needs a bike with a short distance between highest and lowest position of the pedals relative to her seat. In addition it needs to be VERY low to the ground in order to be able to get onto the seat. That means a lower than usual bottom bracket.
A lot of these issues are the legacy of a head on crash that we both miraculously survived in 1980. Which is part of the story of why I unicycle too but that is another story for another time.
I am aware that many foldup bikes have the bottom bar higher than the bottom bracket but I have seen at least one that the bottom bracket was way down. Combined with 20" wheels and fitted with 140mm cranks it would be the best chance of success. Something like: